Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

Oxygen Generation Influx and Mitochondrial Reactive 2+ of DRAK2 in Response to TCR-Induced Ca Protein Kinase D Orchestrates the Activation

Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold‐Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction

BACKGROUND Environmental cold-induced hypertension is common, but how to treat cold-induced hypertension remains an obstacle. Transient receptor potential melastatin subtype 8 (TRPM8) is a mild cold-sensing nonselective cation channel that is activated by menthol. Little is known about the effect of TRPM8 activation by menthol on mitochondrial Ca2+ homeostasis and the vascular function in cold-...

Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells.

Disturbances of endoplasmic reticulum (ER) Ca2+ homeostasis or protein processing can lead to ER stress-induced cell death. Increasing evidence suggests that oxidative stress (OS) plays an important role in a variety of cell death mechanisms. To investigate the role of OS in ER stress, we measured OS in response to three ER stress agents: econazole (Ec), which stimulates ER Ca2+ release and blo...

Interplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy

Objective(s):  The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy. Results:In present study Endothelin treated car...

بررسی اثرات عروقی تجویز مزمن 2 داروی سولفونیل اوره از نسل اول(کلرپروپامید) و نسل دوم(گلی‌بن‌کلامید) بر عمل‌کرد آئورت سینه‌ای موش صحرایی سالم

Diabetes mellitus is one of the most common endocrine disorders with increasing prevalence. Cardiovascular complications are among the major causes of death in diabetic patients. Type II diabetes mellitus is generally treated with sulfonylureas. There are controversial reports regarding adverse cardiovascular effects of these drugs. Also evidence exists about differences in side effec...